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| The proliferation of blood cells in leukaemia is just one example of unchecked tissue growth associated with cancer - but the extent to which external and internal factors drive this process is open to debate. |
Cancer studies clash over mechanisms of malignancy
by Heidi Ledford, nature.com,
16 December 2015
Debate surrounds relative importance of environmental and intrinsic factors.
Most cases of cancer result from avoidable factors such as toxic chemicals and radiation, contends a study published online in Nature on 16 December (S. Wu et al. Naturehttp://dx.doi.org/10.1038/nature16166; 2015). The paper attempts to rebut an argument that arose early this year, when a report in Science concluded that differences in inherent cellular processes are the chief reason that some tissues become cancerous more frequently than others (C. Tomasetti and B. Vogelstein Science 347, 78–81; 2015).
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Debate surrounds relative importance of environmental and intrinsic factors.
Most cases of cancer result from avoidable factors such as toxic chemicals and radiation, contends a study published online in Nature on 16 December (S. Wu et al. Naturehttp://dx.doi.org/10.1038/nature16166; 2015). The paper attempts to rebut an argument that arose early this year, when a report in Science concluded that differences in inherent cellular processes are the chief reason that some tissues become cancerous more frequently than others (C. Tomasetti and B. Vogelstein Science 347, 78–81; 2015).